Effect of Dengue Virus on Procoagulant and Fibrinolytic Activities of Monocytes

Dengue viruses are flaviruses that comprise four distinct types (dengue types 1-4). These viruses are transmitted by the domestic mosquito Aedes aegypti and cause disease with two different clinical manifestations, one mild, i.e., dengue fever(DF); and the other life threatening, leading to shock an...

Full description

Saved in:
Bibliographic Details
Main Authors: Krishnamurti, Chitra, Alving, Barbara
Format: Report
Language:English
Subjects:
ACTIVATION
ADULTS
AEDES
AEDES AEGYPTI
ASS13
BLOOD COAGULATION
CHILDREN
CULICIDAE
DENGUE
DENGUE HEMORRHAGIC FEVER
DENGUE SHOCK SYNDROME
DENGUE VIRUSES
DOMESTIC
ENZYME PRECURSORS
ENZYMES
FEVERS
FIBRINOLYSIS
FLAVIRUSES
HEMORRHAGIC FEVERS
IN VITRO ANALYSIS
IN VIVO ANALYSIS
INFECTIOUS DISEASES
LIMITATIONS
Medicine and Medical Research
Microbiology
MONOCYTES
PAI(PLASMINOGEN ACTIVATOR SPECIFIC INHIBITOR)
PE61102A
PHOSPHORUS TRANSFERASES
PROCOAGULATION
PRODUCTION
REPRINTS
SHOCK(PATHOLOGY)
SIGNS AND SYMPTOMS
SUPERNATANTS
UROKINASE
VIRUSES
WU309
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dengue viruses are flaviruses that comprise four distinct types (dengue types 1-4). These viruses are transmitted by the domestic mosquito Aedes aegypti and cause disease with two different clinical manifestations, one mild, i.e., dengue fever(DF); and the other life threatening, leading to shock and known as dengue shock syndrome or dengue hemorrhagic fever (DSS/DHF). DF is typically seen in adults, whereas DHF/DSS occurs predominantly in children. Some of the fibrinolytic and coagulant enzymes that monocytes produce are urokinase, a plasminogen activator (PA); a PA-specific inhibitor (PAI); and procoagulant activity (PCA) which has been characterized as tissue factor. Dengue infection in vivo is restricted to monocytes; however, it is unknown if dengue-infected monocytes undergo alterations in the production of PA, PAI, and PCA activities. This issue was addressed in studies in which monocytes were infected in vitro with dengue 2 virus in serum-free medium in the presence of enhancing antibody. No urokinase activity was detected in either control or infected cells of in their supernatants. Infection of monocytes with the dengue 2 virus resulted in an almost threefold increase in PAI activity in cells and supernatants. No change in relation to the control was observed in PAA generated by the infected cells. These data indicate that dengue 2 infection enhances the production of PAI from monocytes without altering PA or PCA. Reprints. Pub. in Reviews of Infectious Diseases, v2 suppl4 pS843-S846 May-Jun 1989.