Non-Human Primate Model for Performance Effects of Ethanol

Twenty adult male rhesus monkeys (M. mulatta) ingested various doses of ethanol mixed in orange-flavored drink (10 to 20% ethanol by volume). After each dose, 4-5 blood samples were analyzed to determine peak blood alcohol level (BAL), so as to estimate a dose-response function for each animal. Then...

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Bibliographic Details
Main Authors: Blick, Dennis W, Weathersby, Frank R , Jr, Miller, Stephanie A, Cosgrove, Donald J, Murphy, Michael R
Format: Report
Language:English
Subjects:
ALCOHOL INTOXICATION
Biochemistry
BLOOD ALCOHOL LEVEL
BLOOD SAMPLES
BLOOD VOLUME
DOSAGE
EQUILIBRIUM(PHYSIOLOGY)
ETHANOLS
INCAPACITATION
INGESTION(PHYSIOLOGY)
INTOXICATION
M. MULATTA
MACAQUE
PE62202F
PEAK VALUES
PEP(PRIMATE EQUILIBRIUM PLATFORM)
RESPONSE(BIOLOGY)
RHESUS MONKEYS
Stress Physiology
WUAFRL7757B314
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Summary:Twenty adult male rhesus monkeys (M. mulatta) ingested various doses of ethanol mixed in orange-flavored drink (10 to 20% ethanol by volume). After each dose, 4-5 blood samples were analyzed to determine peak blood alcohol level (BAL), so as to estimate a dose-response function for each animal. Then, in different (but balanced) random orders, the animals received ethanol doses estimated to produce BALs of 0.00, 0.08, 0.12, 0.16, and 0.20%. Performance of a well-trained compensatory tracking task, the Primate Equilibrium Platform (PEP) task, was tested for 2 hr, commencing 30 min after the beginning of ethanol ingestion (which was completed in 15 min). BAL was determined at 30 min intervals before, during, and after PEP testing. The significant and dose-related performance decrements induced by ethanol varied in severity from nearly undetectable at the lowest dose to periods of incapacitation in many subjects at the highest dose.