Early Support of Intracranial Perfusion

This report represents the fifth in a multi-year effort to improve outcomes in patients with traumatic brain injury (TBI) utilizing human and animal models. The first two years focused on infrastructure development, development of a basic science protocol, development and institution of two human us...

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Bibliographic Details
Main Authors: Scalea, Thomas, Stein, Deborah, Gettings, Lisa, Murdock, Karen
Format: Report
Language:English
Subjects:
Anatomy and Physiology
BLOOD PRESSURE
CENTRAL NERVOUS SYSTEM
CLINICAL MEDICINE
CRANIAL NERVES
CYTOKINES
DATA ACQUISITION
DATA BASES
DECISION MAKING
DIAGNOSIS(MEDICINE)
EPIDEMIOLOGY
INFLAMMATION
INTRACRANIAL PERFUSION
MEDICAL PERSONNEL
Medicine and Medical Research
MORTALITY RATE
NEUROTRAUMA
OUTCOMES
PATIENTS
POLYTRAUMA
PRE-HOSPITAL CARE
RATS
REGRESSION ANALYSIS
RESUSCITATION
SIGNAL PROCESSING
SIGNS AND SYMPTOMS
TRAUMATIC BRAIN INJURIES
VITAL SIGNS
WOUNDS AND INJURIES
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Summary:This report represents the fifth in a multi-year effort to improve outcomes in patients with traumatic brain injury (TBI) utilizing human and animal models. The first two years focused on infrastructure development, development of a basic science protocol, development and institution of two human use protocols, staff acquisition, equipment purchase and development of a Brain Resuscitation Registry (BRR) to provide structure and linkage capabilities for data collection and outcome reporting. Year 3 accomplishments included the ongoing enrollment of subjects in the human use protocols focusing on the inflammatory process following TBI and vital sign response to trauma, development and implementation of 2 retrospective human use protocols, processing of specimens for the Cytokines sub-project, further development of the BRR and initiation of the basic science model including both small and large animal models of polytrauma. During Year 4 the existing human use protocols concluded data collection and neared finalization of data analysis, and a new protocol was proposed. Progress continued in BRR development and reporting, and the animal sub-project neared completion. Year 5 saw completion of data analysis for the Cytokines and Animal sub-projects, ongoing analysis of the Vital Signs sub-project, and continued development of the final human use sub-project. A no-cost extension was granted in September 2012, to allow for completion of the final human use protocol.