Relation of Short Stature to Outcomes in Korean Patients Undergoing Primary Percutaneous Coronary Intervention for Acute ST-Elevation Myocardial Infarction (From the INTERSTELLAR Registry)

• Published in: The American journal of cardiology 2016
• Main Authors: Moon, Jeonggeun, MD, Suh, Jon, MD, Oh, Pyung Chun, MD, Lee, Kyounghoon, MD, Park, Hyun Woo, MD, Jang, Ho-Jun, MD, Kim, Tae-Hoon, MD, Park, Sang-Don, MD, Kwon, Sung Woo, MD, Kang, Woong Chol, MD
• Format: Article
• Language: English
• Subjects: Cardiovascular
• ISSN: 0002-9149
• DOI: 10.1016/j.amjcard.2016.04.046

Abstract Although epidemiologic studies have shown the impact of height on occurrence and/or prognosis of cardiovascular diseases, the underlying mechanism is unclear. In addition, the relationship in ST-segment elevation myocardial infarction (STEMI) patients underwent primary percutaneous coronary intervention (PCI) remains unknown. We sought to assess the influence of height on outcomes of acute STEMI patients undergoing primary PCI and to provide a pathophysiological explanation. All 1,490 STEMI patients undergoing primary PCI were analyzed. Major adverse cardiac and cerebrovascular events (MACCE) were defined as all-cause mortality, non-fatal myocardial infarction, non-fatal stroke, and unplanned hospitalization for heart failure (HF). Patients were divided into: 1) MACCE (+) vs. MACCE (-) and 2) 1st - to 3rd -tertile groups according to height. MACCE (+) group was shorter than MACCE (-) group (164±8 vs. 166±8 cm, p=0.012). Prognostic impact of short stature was significant in older (≥70 years) male patients even after adjusting for comorbidities (hazard ratio: 0.951, 95% confidence interval: 0.912-0.991, p=0.017). The 1st -tertile group showed the worst MACCE-free survival (p=0.035), and most cases of MACCE were HF (n, 17 [3%] vs. 6 [1%] vs. 2 [0%], p=0.004). On post-PCI echocardiography, left atrial volume and early diastolic mitral velocity to early diastolic mitral annulus velocity ratio showed an inverse relationship with height (p