Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease

Histone deacetylase 6 (HDAC6) is a potential target for Alzheimer's disease (AD). In this study, a series of novel phenothiazine-, memantine-, and 1,2,3,4-tetrahydro-γ-carboline-based HDAC6 inhibitors with a variety of linker moieties were designed and synthesized. As a hydrochloride salt, the...

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Bibliographic Details
Published in:	European journal of medicinal chemistry 2021-12, Vol.225, p.113821, Article 113821
Main Authors:	Wang, Xiu-Xiu, Xie, Fei, Jia, Cong-Cong, Yan, Ning, Zeng, Yan-Li, Wu, Jing-De, Liu, Zhao-Peng
Format:	Article
Language:	English
Subjects:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Cell Survival - drug effects Copper - metabolism Dose-Response Relationship, Drug HDAC6 inhibitors Histone Deacetylase 6 - antagonists & inhibitors Histone Deacetylase 6 - metabolism Histone Deacetylase Inhibitors - chemical synthesis Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - pharmacology Humans Molecular Structure Multifunctional agents Neurite outgrowth Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Peptide Fragments - antagonists & inhibitors Peptide Fragments - metabolism Structure-Activity Relationship Tau Tumor Cells, Cultured
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