Altered Protein Abundance and Localization Inferred from Sites of Alternative Modification by Ubiquitin and SUMO

[Display omitted] •Sites of Alternative Modifications (SAMs) are more abundant than previously appreciated.•SUMO-ubiquitin SAMs are revealed in more than 4000 proteins across the proteome.•Ubiquitin-SUMO SAM proteins have increased protein abundance and altered cyto-nuclei localization.•SAM-associat...

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Bibliographic Details
Published in:Journal of molecular biology 2021-10, Vol.433 (21), p.167219, Article 167219
Main Authors: Ulman, Adi, Levin, Tal, Dassa, Bareket, Javitt, Aaron, Kacen, Assaf, Shmueli, Merav D., Eisenberg-Lerner, Avital, Sheban, Daoud, Fishllevich, Simon, Levy, Emmanuel D., Merbl, Yifat
Format: Article
Language:English
Subjects:
cell cycle
DNA damage
humans
lysine
molecular biology
phenotype
post-translational modification (PTM)
proteome
proteostasis
solvents
SUMO
transcription (genetics)
ubiquitin
Ubiquitin-like (Ubl)
ubiquitination
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