A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen, heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic...

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Bibliographic Details
Published in:Tetrahedron 2019-11, Vol.75 (45), p.130527, Article 130527
Main Authors: Fesenko, Anastasia A., Yankov, Alexander N., Shutalev, Anatoly D.
Format: Article
Language:English
Subjects:
aldehydes
alkylation agents
Amidoalkylation
Antibacterial and antifungal activity
antibacterial properties
antifungal properties
carbon
chemical reactions
hydrogen
in vitro studies
Lewis bases
minimum inhibitory concentration
moieties
Nucleophiles
Semicarbazones
sodium borohydride
Sulfones
Three-component condensation
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