Mismatch Repair

Highly conserved MutS homologs (MSH) and MutL homologs (MLH/PMS) are the fundamental components of mismatch repair (MMR). After decades of debate, it appears clear that the MSH proteins initiate MMR by recognizing a mismatch and forming multiple extremely stable ATP-bound sliding clamps that diffuse...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of biological chemistry 2015-10, Vol.290 (44), p.26395-26403
Main Author: Fishel, Richard
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - genetics
Adenosine Triphosphate - metabolism
Animals
cancer biology
DNA - genetics
DNA - metabolism
DNA mismatch repair
DNA Mismatch Repair - physiology
DNA repair
DNA Repair Enzymes - genetics
DNA Repair Enzymes - metabolism
hereditary non-polyposis colorectal cancer
hMLH1
hMSH2
Humans
Lynch syndrome
Minireviews
mutagenesis
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
single molecule analysis
single-molecule biophysics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!