CAR-HEMATOTOX: a model for CAR T-cell–related hematologic toxicity in relapsed/refractory large B-cell lymphoma

Hematotoxicity represents a frequent chimeric antigen receptor (CAR) T-cell–related adverse event and remains poorly understood. In this multicenter analysis, we studied patterns of hematopoietic reconstitution and evaluated potential predictive markers in 258 patients receiving axicabtagene ciloleu...

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Bibliographic Details
Published in:Blood 2021-12, Vol.138 (24), p.2499-2513
Main Authors: Rejeski, Kai, Perez, Ariel, Sesques, Pierre, Hoster, Eva, Berger, Carolina, Jentzsch, Liv, Mougiakakos, Dimitrios, Frölich, Lisa, Ackermann, Josephine, Bücklein, Veit, Blumenberg, Viktoria, Schmidt, Christian, Jallades, Laurent, Fehse, Boris, Faul, Christoph, Karschnia, Philipp, Weigert, Oliver, Dreyling, Martin, Locke, Frederick L., von Bergwelt-Baildon, Michael, Mackensen, Andreas, Bethge, Wolfgang, Ayuk, Francis, Bachy, Emmanuel, Salles, Gilles, Jain, Michael D., Subklewe, Marion
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anemia - etiology
Antineoplastic Agents, Immunological - adverse effects
Antineoplastic Agents, Immunological - therapeutic use
Biological Products - adverse effects
Biological Products - therapeutic use
Cytokine Release Syndrome - etiology
Hematologic Diseases - etiology
Humans
Immunobiology and Immunotherapy
Immunotherapy, Adoptive - adverse effects
Incidence
Life Sciences
Lymphoma, Large B-Cell, Diffuse - therapy
Middle Aged
Neoplasm Recurrence, Local - therapy
Neurotoxicity Syndromes - etiology
Neutropenia - etiology
Receptors, Antigen, T-Cell - therapeutic use
Retrospective Studies
Thrombocytopenia - etiology
Young Adult
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