Simultaneous Quantification of Mitochondrial DNA Damage and Copy Number in Circulating Blood: A Sensitive Approach to Systemic Oxidative Stress

Systemic oxidative stress is associated with a wide range of pathological conditions. Oxidative DNA damage is frequently measured in circulating lymphocytes. Mitochondrial DNA (mtDNA) is known to be more sensitive to oxidative damage than nuclear DNA but is rarely used for direct measurement of DNA...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-10
Main Authors: Chen, Junjian Z., Aprikian, Armen, Chevalier, Simone, Chan, Sam W.
Format: Article
Language:English
Subjects:
Adult
Analysis
Blood
Cell Line, Tumor
DNA Damage
DNA, Mitochondrial - blood
Humans
Hydrogen Peroxide - pharmacology
Lymphocytes - metabolism
Male
Methods
Middle Aged
Mitochondrial DNA
Oxidants - pharmacology
Oxidative Stress
Physiological aspects
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