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Determination of mefenamic acid using a new mode of irradiation (array of six identical LEDs) and detection (twin solar cells) through turbidity measurement by CFIA

A newly developed analytical method characterized by its speed and sensitivity for the determination of mefenamic acid (MFA) in pure and pharmaceutical preparation is established via turbidimetric measurement (0-180o) by Ayah 6SX1-ST-2D Solar cell CFI Analyser . The method was based on the reaction...

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Bibliographic Details
Published in:Iraqi journal of science 2016, Vol.57 (2B), p.1052-1070
Main Authors: al-Awwadi, Nagham Shakir Turki, al-Saidi, Mustafa Karim Kazim
Format: Article
Language:ara ; eng
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Summary:A newly developed analytical method characterized by its speed and sensitivity for the determination of mefenamic acid (MFA) in pure and pharmaceutical preparation is established via turbidimetric measurement (0-180o) by Ayah 6SX1-ST-2D Solar cell CFI Analyser . The method was based on the reaction of phosphomolybdic acid with mefenamic acid in aqueous medium to form blue color precipitate as an ion-pair complex . Turbidity was measured via the reflection of incident light that collides on the surface precipitated particles at 0-180o . The chemical and physical parameters were studied and optimized. The calibration graph was linear in the range of 0.3-7 or 0.3-10 mMol.L-1, with correlation coefficient r = 0.9907 or 0.9556 respectively. The limit of detection 4.92 μg/sample from the step wise dilution for the minimum concentration in the linear dynamic ranged of the calibration graph with RSD% lower than 0.3% for 3 and 5 mMol.L-1 ( n= 6,10 respectively ) concentration of mefenamic acid. The method was successfully applied to the determination of mefenamic acid in four pharmaceuticals . A comparison was made between the newly developed method analysis and the classical method , in addition to between four different pharmaceutical preparations (UV- spectrophotometry at wave length 222 nm) using the standard additions method via the use of t-test. It was noticed that there was no significant difference between two methods at 95 % confidence level and significant difference between four drugs.
ISSN:0067-2904
2312-1637