Loading…
Effects of Sleep and Sleep Deprivation on Catecholamine And Interleukin-2 Levels in Humans: Clinical Implications1
The objective of this study was to evaluate the effects of nocturnal sleep, partial night sleep deprivation, and sleep stages on catecholamine and interleukin-2 (IL-2) levels in humans. Circulating levels of catecholamines and IL-2 were sampled every 30 min during 2 nights: undisturbed, baseline sle...
Saved in:
Published in: | The journal of clinical endocrinology and metabolism 1999-06, Vol.84 (6), p.1979-1985 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The objective of this study was to evaluate the effects of nocturnal
sleep, partial night sleep deprivation, and sleep stages on
catecholamine and interleukin-2 (IL-2) levels in humans. Circulating
levels of catecholamines and IL-2 were sampled every 30 min during 2
nights: undisturbed, baseline sleep and partial sleep deprivation-late
night (PSD-L; awake from 0300–0600 h) in 17 healthy male volunteers.
Sleep was monitored somnopolygraphically. Sleep onset was associated
with a significant (P < 0.05) decline of
circulating concentrations of norepinephrine and epinephrine, with a
nocturnal nadir that occurred 1 h after nocturnal sleep. On the
PSD-L night, levels of norepinephrine and epinephrine significantly
(P < 0.05) increased in association with nocturnal
awakening. During stage 3–4 sleep, levels of norepinephrine, but not
epinephrine, were significantly lower (P < 0.05)
compared to average levels during the awake period, stages 1–2 sleep,
and rapid eye movement sleep. Nocturnal levels of circulating IL-2 did
not change with sleep onset or in relation to PSD-L or the various
sleep stages.
We conclude that sleep onset is associated with changes in levels of
circulating catecholamines. Loss of sleep and disordered sleep with
decreases in slow wave sleep may serve to elevate nocturnal
catecholamine levels and contribute to cardiovascular disease. |
---|---|
ISSN: | 0021-972X 1945-7197 |
DOI: | 10.1210/jcem.84.6.5788 |