Comparative effect of repeated ingestion of difructose anhydride III and palatinose on the induction of gastrointestinal symptoms in humans

We evaluated the safety and change in fermentability from repeated ingestion of difructose anhydride III (DFAIII) in humans. A randomized controlled singleblind crossover study with thirteen subjects was conducted. Each subject ingested 5g of DFAIII or palatinose daily for 12 days, before and after...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2004-09, Vol.68 (9), p.1882-1887
Main Authors: Tamura, A. (FANCL Corp., Yokohama (Japan). Central Research Center), Shiomi, T, Tamaki, N, Shigematsu, N, Tomita, F, Hara, H
Format: Article
Language:English
Subjects:
Abdominal Pain - chemically induced
Abdominal Pain - microbiology
Adult
Biological and medical sciences
breath hydrogen
Breath Tests
Cross-Over Studies
difructose anhydride III (DFAIII)
Disaccharides - administration & dosage
Disaccharides - adverse effects
Enterobacteriaceae - growth & development
Enterobacteriaceae - metabolism
Feces - chemistry
Fermentation
Flatulence - chemically induced
Flatulence - microbiology
FOOD INTAKE
FRUCTOSE
Fundamental and applied biological sciences. Psychology
Humans
Hydrogen - analysis
INTESTINES
Isomaltose - administration & dosage
Isomaltose - adverse effects
Isomaltose - analogs & derivatives
MANKIND
MICROBIAL FLORA
Middle Aged
Nausea - chemically induced
Nausea - microbiology
OLIGOSACCHARIDES
repeated ingestion
SAFETY
Single-Blind Method
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Summary:We evaluated the safety and change in fermentability from repeated ingestion of difructose anhydride III (DFAIII) in humans. A randomized controlled singleblind crossover study with thirteen subjects was conducted. Each subject ingested 5g of DFAIII or palatinose daily for 12 days, before and after which the subject was loaded with 10 g of DFAIII and had breath hydrogen measured from 0 to 9 h (DL test) to evaluate the fermentability of DFAIII. The defecation frequency and abdominal symptom score were the same between each ingestion period. Moreover, DFAIII ingestion had no influence on blood test results. Only the breath hydrogen excretion in post-DFAIII ingestion was slightly higher at h 8 than the pre-ingestion. Consequently, repeated ingestion of DFAIII for 12 days was as safe as palatinose ingestion, especially with respect to abdominal symptoms and blood test results, and its high resistance to enterobacterial fermentation in humans was not impaired.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.68.1882