Suppression of the systemic immune response to casein [in mice] by oral administration of a tryptic digest of casein

The systemic immune response against orally administered antigens is suppressed (oral tolerance), and this has been postulated to avoid excess immunity against dietary constituents which are present in large amounts in the gastrointestinal tract. Taking into consideration that such orally administer...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1993, Vol.57 (10), p.1674-1677
Main Authors: Hachimura, S. (Tokyo Univ. (Japan)), Takahashi, Y, Fujikawa, Y, Tsumori, C, Enomoto, A, Yoshino, U, Kaminogawa, S
Format: Article
Language:English
Subjects:
Biological and medical sciences
CASEIN
CASEINA
CASEINE
DETERIORATION
DETERIORO
DIGESTION
Fundamental and applied biological sciences. Psychology
Fundamental immunology
IMMUNE RESPONSE
Immunobiology
Immunological tolerance
MICE
PHYSIOLOGICAL REGULATION
RATON
REGULACION FISIOLOGICA
REGULATION PHYSIOLOGIQUE
REPONSE IMMUNITAIRE
RESPUESTA INMUNOLOGICA
SOURIS
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Summary:The systemic immune response against orally administered antigens is suppressed (oral tolerance), and this has been postulated to avoid excess immunity against dietary constituents which are present in large amounts in the gastrointestinal tract. Taking into consideration that such orally administered protein antigens are subjected to enzymatic degradation in the gastrointestinal tract, we examined whether an enzymatic digest of milk proteins could induce oral tolerance. A tryptic digest of casein, containing mainly fragments smaller than 6000 Da, was fed to mice as a constituent of their diet. Mice fed with the casein-digest diet responded poorly to subsequent immunization with casein, indicating that oral tolerance to casein was induced in these animals. The results suggest the presence of immunosuppressive fragment(s) in the casein digest, which may be of use for preventing milk allergy.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.57.1674