role of CD8⁺CD28⁻ regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand

Myasthenia gravis (MG) and experimental autoimmune MG are T cell-dependent antibody-mediated autoimmune diseases. A dual altered peptide ligand (APL), composed of the tandemly arranged two single amino acid analogs of two myasthenogenic peptides, p195-212 and p259-271, down-regulated in vitro and in...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (44), p.17459-17464
Main Authors:	Ben-David, Hava, Sharabi, Amir, Dayan, Molly, Sela, Michael, Mozes, Edna
Format:	Article
Language:	English
Subjects:	acetylcholine amino acid derivatives Animals Antibodies apoptosis autoimmune diseases bcl-X Protein - metabolism Biological Sciences Caspase 3 - metabolism Caspase 8 - metabolism caspase-3 CD28 Antigens - metabolism CD4-Positive T-Lymphocytes - metabolism CD8 Antigens - genetics CD8 Antigens - metabolism CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Cells, Cultured Cellular immunity cholinergic receptors Down-Regulation Female Forkhead Transcription Factors - metabolism gene expression Immunization interferon-gamma interleukin-10 Interleukin-10 - metabolism Interleukin-2 Receptor alpha Subunit - metabolism knockout mutants Ligands Lymph nodes mechanism of action Messenger RNA Mice Mice, Knockout Myasthenia gravis Myasthenia Gravis - immunology Myasthenia Gravis - metabolism Peptides - metabolism population growth Receptors, Nicotinic - immunology Secretion T lymphocytes Torpedo Torpedo - immunology transforming growth factor beta Transforming Growth Factor beta - metabolism Up regulation
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