MARIPOSA: phase 3 study of first-line amivantamab + lazertinib versus osimertinib in EGFR-mutant non-small-cell lung cancer

Third-generation EGFR tyrosine kinase inhibitors (TKIs), such as osimertinib, have demonstrated efficacy in patients with -mutant non-small-cell lung cancer; however, almost all patients will eventually relapse. Amivantamab is an EGFR-MET bispecific antibody with immune cell-directing activity that...

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Published in:	Future oncology (London, England) England), 2022-02, Vol.18 (6), p.639-647
Main Authors:	Cho, Byoung Chul, Felip, Enriqueta, Hayashi, Hidetoshi, Thomas, Michael, Lu, Shun, Besse, Benjamin, Sun, Tao, Martinez, Melissa, Sethi, Seema N, Shreeve, S Martin, Spira, Alexander I
Format:	Article
Language:	English
Subjects:	Acrylamides - adverse effects Acrylamides - therapeutic use Adolescent Adult amivantamab Aniline Compounds - adverse effects Aniline Compounds - therapeutic use Antibodies, Bispecific - adverse effects Antibodies, Bispecific - therapeutic use Antineoplastic Agents, Immunological - adverse effects Antineoplastic Agents, Immunological - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Clinical Trials, Phase III as Topic EGFR mutations ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Humans lazertinib Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Morpholines - adverse effects Morpholines - therapeutic use Multicenter Studies as Topic Mutation Neoplasm Metastasis non-small-cell lung cancer Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pyrazoles - adverse effects Pyrazoles - therapeutic use Pyrimidines - adverse effects Pyrimidines - therapeutic use Randomized Controlled Trials as Topic Research Design tyrosine kinase inhibitors Young Adult
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