Interaction of Host Nucleolin with Influenza A Virus Nucleoprotein in the Early Phase of Infection Limits the Late Viral Gene Expression

Influenza A virus nucleoprotein, is a multifunctional RNA-binding protein, encoded by segment-5 of the negative sense RNA genome. It serves as a key connector between the virus and the host during virus replication. It continuously shuttles between the cytoplasm and the nucleus interacting with vari...

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Bibliographic Details
Published in:	PloS one 2016-10, Vol.11 (10), p.e0164146
Main Authors:	Kumar, Deepshikha, Broor, Shobha, Rajala, Maitreyi S.
Format:	Article
Language:	English
Subjects:	Analysis Animals Biology and Life Sciences Biotechnology Cell Line, Tumor Cytoplasm Dogs Gene expression Gene Expression Regulation, Viral Genes Genomes Genomics Health aspects Hemagglutinins Hepatitis Humans Immunoprecipitation Infections Influenza Influenza A Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - metabolism Influenza A Virus, H1N1 Subtype - physiology Influenza, Human - epidemiology Influenza, Human - metabolism Influenza, Human - virology Life cycle engineering Life cycles Madin Darby Canine Kidney Cells Medicine and Health Sciences Nuclei Nuclei (cytology) Nucleocapsid Proteins Nucleoli Nucleolin Pandemics Phosphoproteins - deficiency Phosphoproteins - genetics Phosphoproteins - metabolism Protein Binding Proteins Ribonucleic acid RNA RNA Interference RNA, Small Interfering - genetics RNA-binding protein RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Seasons siRNA Transcription, Genetic Viral Core Proteins - genetics Viral Core Proteins - metabolism Viral proteins Virology Viruses
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