Absence of Association between Cord Specific Antibody Levels and Severe Respiratory Syncytial Virus

The target group for severe respiratory syncytial virus (RSV) disease prevention is infants under 6 months of age. Vaccine boosting of antibody titres in pregnant mothers could protect these young infants from severe respiratory syncytial virus (RSV) associated disease. Quantifying protective levels...

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Bibliographic Details
Published in:PloS one 2016-11, Vol.11 (11), p.e0166706
Main Authors: Nyiro, Joyce Uchi, Sande, Charles Jumba, Mutunga, Martin, Kiyuka, Patience Kerubo, Munywoki, Patrick Kioo, Scott, John Anthony G, Nokes, David James
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Disease susceptibility
Infants
Medical research
Pediatric diseases
Pregnant women
Prevention
Vaccines
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Summary:The target group for severe respiratory syncytial virus (RSV) disease prevention is infants under 6 months of age. Vaccine boosting of antibody titres in pregnant mothers could protect these young infants from severe respiratory syncytial virus (RSV) associated disease. Quantifying protective levels of RSV-specific maternal antibody at birth would inform vaccine development. A case control study nested in a birth cohort (2002-07) was conducted in Kilifi, Kenya; where 30 hospitalised cases of RSV-associated severe disease were matched to 60 controls. Participants had a cord blood and 2 subsequent 3-monthly blood samples assayed for RSV-specific neutralising antibody by the plaque reduction neutralisation test (PRNT). Two sample paired t test and conditional logistic regression were used in analyses of log.sub.2 PRNT titres. The mean RSV log.sub.2 PRNT titre at birth for cases and controls were not significantly different (P = 0.4) and remained so on age-stratification. Cord blood PRNT titres showed considerable overlap between cases and controls. The odds of RSV disease decreased with increase in log.sub.2 PRNT cord blood titre. There was a 30% reduction in RSV disease per unit increase in log.sub.2 PRNT titre (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0166706