A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans

Apical extracellular matrices (aECMs) act as crucial barriers, and communicate with the epidermis to trigger protective responses following injury or infection. In Caenorhabditis elegans , the skin aECM, the cuticle, is produced by the epidermis and is decorated with periodic circumferential furrows...

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Bibliographic Details
Published in:PLoS genetics 2025-03, Vol.21 (3), p.e1011593
Main Authors: Sonntag, Thomas, Omi, Shizue, Andreeva, Antonina, Valotteau, Claire, Eichelbrenner, Jeanne, Chisholm, Andrew D., Ward, Jordan D., Pujol, Nathalie
Format: Article
Language:English
Subjects:
Animals
Animals Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans / genetics Cysteine / genetics Cysteine / metabolism Epidermis / metabolism Extracellular Matrix / genetics Extracellular Matrix / metabolism Mutation Signal Transduction Skin / metabolism Skin / pathology
Biology and Life Sciences
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Caenorhabditis elegans - growth & development
Caenorhabditis elegans - immunology
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - metabolism
Collagen
Cuticles
Cysteine
Cysteine - genetics
Cysteine - metabolism
Data collection
Developmental stages
Epidermis
Epidermis - immunology
Epidermis - metabolism
Extracellular matrix
Extracellular Matrix - genetics
Extracellular Matrix - metabolism
Extracellular Matrix Proteins - genetics
Extracellular Matrix Proteins - metabolism
Genes
Genetic screening
Immune response
Infections
Life Sciences
Medicine and Health Sciences
Molting
Mutation
Peptides
Physical Sciences
Physiological aspects
Proteins
Research and Analysis Methods
Signal Transduction - genetics
Skin
Skin - metabolism
Worms
Young adults
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