New methodology for functionalization of the imidazole ring by alkynes

A new methodology for functionalization of the imidazole ring via the zwitterionic intermediates and their carbene tautomers generated by nucleophilic addition of 1-substituted imidazoles to electron-deficient acetylenes followed by reactions with the appropriate electrophiles is discussed.

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2012-04, Vol.48 (1), p.147-154
Main Authors: Trofimov, B. A., Andriyankova, L. V., Belyaeva, K. V.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
Surface active agents
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Description
Summary:A new methodology for functionalization of the imidazole ring via the zwitterionic intermediates and their carbene tautomers generated by nucleophilic addition of 1-substituted imidazoles to electron-deficient acetylenes followed by reactions with the appropriate electrophiles is discussed.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-012-0978-2