Synthesis and antitumor activity of a series of benzofuryl-substituted 1,2,4-triazoles and triazolin-5-thiones

3-Benzofuryl-4-benzyl(cyclohexyl)-5-mercapto-1,2,4-triazoles were synthesized by cyclization of the corresponding substituted thiosemicarbazides. 5-Mercaptotriazoles were S-alkylated with various alkenyl-substituted benzylhalogenides, chloracetamide, chloroacetic, and α-bromopropionic and α-bromocap...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2011-07, Vol.45 (4), p.211, Article 211
Main Authors: Kaldrikyan, M. A., Grigoryan, L. A., Melik-Ogandzhanyan, R. G., Arsenyan, F. G.
Format: Article
Language:English
Subjects:
Hydroxides
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Triazoles
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Summary:3-Benzofuryl-4-benzyl(cyclohexyl)-5-mercapto-1,2,4-triazoles were synthesized by cyclization of the corresponding substituted thiosemicarbazides. 5-Mercaptotriazoles were S-alkylated with various alkenyl-substituted benzylhalogenides, chloracetamide, chloroacetic, and α-bromopropionic and α-bromocaproic acids. The aminomethylation and hydroxymethylation reactions of 3-benzofuryl-4-benzyl(cyclohexyl)-5-mercapto-1,2,4-triazoles were studied. The antitumor activity of the resulting compounds was investigated.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0596-9