Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives

A base-catalyzed conversion of aldehydes to benzimidazoles has been achieved. The compounds have been characterized by IR, NMR, micoranalysis, and GC-MS. The reaction for the formation of benzimidazoles has been monitored with [.sup.1]H NMR and IR. The crystal structures of two derivatives, 2-(2-chl...

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Bibliographic Details
Published in:Bulletin of the Chemical Society of Ethiopia 2018-01, Vol.32 (2), p.271
Main Authors: Odame, F., Krause, J., C. Hosten, E., Betz, R., Lobb, K., R. Tshentu, Z., L. Frost, C.
Format: Article
Language:English
Subjects:
Analysis
Benzimidazoles
Catalysis
Chemical synthesis
Properties
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Summary:A base-catalyzed conversion of aldehydes to benzimidazoles has been achieved. The compounds have been characterized by IR, NMR, micoranalysis, and GC-MS. The reaction for the formation of benzimidazoles has been monitored with [.sup.1]H NMR and IR. The crystal structures of two derivatives, 2-(2-chlorophenyl)-1H-benzimidazole and 2-(1H-benzimidazol-2-yl)-4-nitrophenol, are presented. A study of the DPPH scavenging activity of these compounds showed that 2-(1H-benzimidazol-2-yl)phenol (2), 2-p-tolyl-1H-benzimidazole (3) and 2-(4-methoxyphenyl)-1H-benzimidazole (7) gave I[C.sub.50] values 1974, 773 and 800 [micro]M. KEY WORDS: Benzimidazole, o-Phenylenediamine, Aldehydes, Base catalysis, DPPH scavenging activity
ISSN:1011-3924
1726-801X
DOI:10.4314/bcse.v32i2.8