Release Kinetics Study and Development of Conditions for Dissolution Test of Afobazole new Prolonged-Release Solid Dosage Form

The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro . The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the diss...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical chemistry journal 2023-04, Vol.57 (1), p.123-128
Main Authors: Sergeeva, M. S., Grushevskaya, L. N., Gaevaya, L. M., Dudenkova, M. E., Denisenko, E. D., Minaev, S. V.
Format: Article
Language:English
Subjects:
Analysis
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Phosphates
Product introduction
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The release kinetics of afobazole from a new solid dosage form of prolonged-release film-coated tablets was studied in vitro . The conditions of the dissolution test were experimentally determined with the use of the basket apparatus type I and phosphate buffer solution pH 6.8 (Eur. Ph.) as the dissolution medium. The specification release limits were ≤25% after 1 h, 45 – 60% after 6 h, and ≥80% after 24 h of the nominal afobazole content in the tablets. The release kinetics of afobazole from the prolonged-release tablets were evaluated using the first-order, Higuchi, and Korsmeyer(Peppas mathematical models. The release mechanism of the active ingredient from the matrix could be characterized as anomalous diffusion according to the Korsmeyer(Pappas model.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-023-02859-4