1,2-Oxidative Trifluoromethylation of Olefin with Ag and O[sub.2]: Synthesis of α-Trifluoromethyl Ketones

A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O[sub.2]CCF[sub.2]SO[sub.2]F) as a trifluoromethyl source is described with O[sub.2] as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasi...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-12, Vol.29 (23)
Main Authors: Zhang, Shengxue, Xiao, Wangchuan, Wu, Jingjing, Wu, Fanhong, Huang, Houjin, Ma, Xiaoyu, Shi, Yafei, Liu, Chao
Format: Article
Language:English
Subjects:
Ketones
Olefins
Online Access:Get full text
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Summary:A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O[sub.2]CCF[sub.2]SO[sub.2]F) as a trifluoromethyl source is described with O[sub.2] as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29235622