Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

Tumours can require certain amino acids for their proliferation, and the diricore method described here helps to identify such restrictive amino acids; using this method in kidney cancer tissue and breast carcinoma cells, the authors observe an association between proline deficiency and upregulation...

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Published in:	Nature (London) 2016-02, Vol.530 (7591), p.490-494
Main Authors:	Loayza-Puch, Fabricio, Rooijers, Koos, Buil, Levi C. M., Zijlstra, Jelle, F. Oude Vrielink, Joachim, Lopes, Rui, Ugalde, Alejandro Pineiro, van Breugel, Pieter, Hofland, Ingrid, Wesseling, Jelle, van Tellingen, Olaf, Bex, Axel, Agami, Reuven
Format:	Article
Language:	English
Subjects:	631/1647/514/1949 631/337/574 631/67/2327 Amino acids Animals Asparaginase - metabolism Asparagine - genetics Asparagine - metabolism Aspartate-Ammonia Ligase - metabolism Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Cell growth Cell Line, Tumor Cell Proliferation Codon Codon - genetics delta-1-Pyrroline-5-Carboxylate Reductase Enzymes Female Gene expression Gene Knockout Techniques Genetic aspects Humanities and Social Sciences Humans Kidney cancer Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidneys letter Leukemia Metabolism Mice multidisciplinary Physiological aspects Proline Proline - biosynthesis Proline - deficiency Proline - metabolism Protein biosynthesis Protein Biosynthesis - genetics Protein synthesis Pyrroline Carboxylate Reductases - deficiency Pyrroline Carboxylate Reductases - genetics Pyrroline Carboxylate Reductases - metabolism Ribonucleic acid Ribosomes Ribosomes - metabolism RNA Science Tumors
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