Shiga toxins — from cell biology to biomedical applications

Key Points Owing to the oligomeric structure of the Shiga toxin receptor-binding B subunit, these toxins cluster glycosphingolipids to mediate their trafficking into cells. Shiga toxins use poorly explored trafficking pathways to enter cells by clathrin-independent endocytosis and to reach intracell...

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Bibliographic Details
Published in:	Nature reviews. Microbiology 2010-02, Vol.8 (2), p.105-116
Main Authors:	Johannes, Ludger, Römer, Winfried
Format:	Article
Language:	English
Subjects:	Animals Antigens, Tumor-Associated, Carbohydrate - metabolism Apoptosis Bacterial toxins Binding sites Biology Biomedical and Life Sciences Biosynthesis Cell Membrane - drug effects Cellular signal transduction E coli Escherichia coli Genes Health aspects Hemodialysis Hemolytic-uremic syndrome Humans Immunotherapy Infectious Diseases Inflammatory bowel disease Life Sciences Medical Microbiology Microbiology Neoplasms - therapy Parasitology Pathogens Peritoneal dialysis review-article Risk factors Shiga Toxins - chemistry Shiga Toxins - metabolism Shiga Toxins - pharmacology Shiga Toxins - therapeutic use Shiga-Toxigenic Escherichia coli - metabolism Shiga-Toxigenic Escherichia coli - pathogenicity Signal Transduction Toxins Virology
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