Opioid-Paracetamol Prescription Patterns and Liver Dysfunction: A Retrospective Cohort Study in a Population Served by a US Health Benefits Organization

Background: Paracetamol (acetaminophen) is the most common cause of acute liver failure (ALF). ALF attributed to paracetamol is most often associated with the following features: an unintentional overdose, a single product, an opioid-paracetamol combination, duration of 325 mg) and prescriber specia...

Full description

Saved in:
Bibliographic Details
Published in:Drug safety 2011-11, Vol.34 (11), p.1079-1088
Main Authors: Mort, Jane R., Shiyanbola, Olayinka O., Ndehi, Lilian N., Xu, Yihua, Stacy, Jane N.
Format: Article
Language:English
Subjects:
Acetaminophen
Analgesics
Biological and medical sciences
Care and treatment
Clinical trial. Drug monitoring
Complications and side effects
Dosage and administration
Drug Safety and Pharmacovigilance
Drug toxicity and drugs side effects treatment
General pharmacology
Liver failure
Medical sciences
Medicine
Medicine & Public Health
Neuropharmacology
Original Research Article
Pharmacology. Drug treatments
Pharmacology/Toxicology
Risk factors
Toxicity: digestive system
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Paracetamol (acetaminophen) is the most common cause of acute liver failure (ALF). ALF attributed to paracetamol is most often associated with the following features: an unintentional overdose, a single product, an opioid-paracetamol combination, duration of 325 mg) and prescriber specialty (dentist, physician assistant), were associated with high-dose paracetamol prescriptions. Liver dysfunction was diagnosed in 3818 cases, and 23.4% of these beneficiaries received an opioid-paracetamol prescription in the 90 days prior to the liver dysfunction diagnosis. Conclusions: Although most opioid-paracetamol prescriptions are written and dispensed for
ISSN:0114-5916
1179-1942
DOI:10.2165/11593100-000000000-00000