Antiviral activity of Anaferon

Anaferon (pediatric formulation) administered in the therapeutic-and-prophylactic regimen to mice receiving intranasally 100% infecting dose of A/California/07/2009(H1N1)v influenza virus exhibited an antiviral effect and 10-fold reduced the production of influenza virus in the lungs of infected mic...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-10, Vol.149 (5), p.612
Main Authors: Shishkina, L.N, Skarnovich, M.O, Kabanov, A.S, Sergeev, A.A, Olkin, S.E, Tarasov, S.A, Belopolskaya, M.V, Sergeeva, S.A, Epstein, O.I, Malkova, E.M, Stavsky, E.A, Drozdov, I.G
Format: Article
Language:English
Subjects:
Antiviral agents
Health aspects
Influenza viruses
Pediatrics
Swine influenza
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Summary:Anaferon (pediatric formulation) administered in the therapeutic-and-prophylactic regimen to mice receiving intranasally 100% infecting dose of A/California/07/2009(H1N1)v influenza virus exhibited an antiviral effect and 10-fold reduced the production of influenza virus in the lungs of infected mice on days 4, 6, and 8 after infection compared to the control (distilled water). The efficiency of Anaferon (pediatric formulation) administered before and after infection with A/California/07/2009(H1N1)v influenza virus was not inferior to the use of Tamiflu after infection. Key Words: influenza virus; Anaferon (pediatric formulation); Tamiflu; oseltamivir; antiviral drugs
ISSN:0007-4888