Synthesis and molecular structure study of 3-methoxy-7α-methyl-6-oxa-9β,14β-estra-1,3,5(10)-trien-17-one in solution

It was established by NMR spectroscopy that the catalytic hydrogenation of 3-methoxy-7α-methyl-6-oxa-14β-estra-1,3,5(10),8-tetraen-17-one leads to the formation of 3-methoxy-7α-methyl-6-oxa-9β,14β-estra-1,3,5(10)-trien-17-one, the structure of which was investigated in solution. The corresponding an...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2012-08, Vol.48 (5), p.704-714
Main Authors: Selivanov, S. I., Morozkina, S. N., Shavva, A. G.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Estrogen
Hydrogenation
Nuclear magnetic resonance spectroscopy
Organic Chemistry
Oxalic acid
Pharmacy
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Summary:It was established by NMR spectroscopy that the catalytic hydrogenation of 3-methoxy-7α-methyl-6-oxa-14β-estra-1,3,5(10),8-tetraen-17-one leads to the formation of 3-methoxy-7α-methyl-6-oxa-9β,14β-estra-1,3,5(10)-trien-17-one, the structure of which was investigated in solution. The corresponding analog with a free hydroxyl group at the position 3 possesses an antiradical activity at the absence of uterotropic effect.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-012-1048-5