Superior recovery profiles of propofol-based regimen as compared to isoflurane-based regimen in patients undergoing craniotomy for primary brain tumor excision: a retrospective study

Purpose Studies comparing the recovery profiles of isoflurane- and propofol-based anesthesia for major intracranial surgery have reported contradictory results. The aim of our study was to clarify the emergence status in both regimens by investigating uniformly managed neuroanesthesia cases. Methods...

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Bibliographic Details
Published in:Journal of anesthesia 2012-10, Vol.26 (5), p.721-727
Main Authors: Miura, Yoshihide, Kamiya, Kouhei, Kanazawa, Kaoru, Okada, Masayuki, Nakane, Masaki, Kumasaka, Airi, Kawamae, Kaneyuki
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia Recovery Period
Anesthesia, General - adverse effects
Anesthesia, General - methods
Anesthesiology
Anesthetics, Inhalation - administration & dosage
Anesthetics, Inhalation - adverse effects
Brain Neoplasms - surgery
Brain tumors
Care and treatment
Craniotomy - methods
Critical Care Medicine
Development and progression
Emergency Medicine
Female
Health aspects
Humans
Intensive
Isoflurane - administration & dosage
Isoflurane - adverse effects
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Pain Medicine
Patient outcomes
Postoperative Complications - etiology
Postoperative Period
Propofol - administration & dosage
Propofol - adverse effects
Retrospective Studies
Risk factors
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Summary:Purpose Studies comparing the recovery profiles of isoflurane- and propofol-based anesthesia for major intracranial surgery have reported contradictory results. The aim of our study was to clarify the emergence status in both regimens by investigating uniformly managed neuroanesthesia cases. Methods The anesthesia database at Yamagata University Hospital covering the period 2002–2005 was retrospectively investigated for adult patients who underwent craniotomy for primary brain tumor excision. General anesthesia was provided by an isoflurane- (ISO group) or propofol-based (PROP group) regimen. Times to extubation and operating room (OR) discharge, perioperative consciousness levels, and perioperative variables were compared. Results Of the 202 surgeries performed during the study period, 77 and 82 patients were anesthetized with isoflurane and propofol, respectively. Demographic data were comparable between the two groups, although the American Society of Anesthesiology grade was worse in the PROP group. Extubation times [39.5 ± 14.6 min (ISO) vs. 29.5 ± 14.9 min (PROP); P  
ISSN:0913-8668
1438-8359
DOI:10.1007/s00540-012-1398-2