Peribulbar block in patients scheduled for eye procedures and treated with clopidogrel

Our hypothesis was that the continuation of clopidogrel does not increase the risk of eye hemorrhage, compared to patients not treated with clopidogrel, when a peribulbar anesthesia is required. Our prospective case-control study enrolled two groups of 1,000 patients scheduled for intraocular eye su...

Full description

Saved in:
Bibliographic Details
Published in:Journal of anesthesia 2012-10, Vol.26 (5), p.779-782
Main Authors: Calenda, Emile, Lamothe, Laure, Genevois, Olivier, Cardon, Annie, Muraine, Marc
Format: Article
Language:English
Subjects:
Aged
Anesthesia
Anesthesia, Local - adverse effects
Anesthesia, Local - methods
Anesthesiology
Care and treatment
Case studies
Case-Control Studies
Clinical Report
Critical Care Medicine
Emergency Medicine
Eye
Eye Hemorrhage - etiology
Health aspects
Hemorrhage
Humans
Intensive
Medicine
Medicine & Public Health
Nerve Block - methods
Ophthalmologic Surgical Procedures - adverse effects
Ophthalmologic Surgical Procedures - methods
Pain Medicine
Patient outcomes
Prevention
Prospective Studies
Risk factors
Surgery
Ticlopidine - administration & dosage
Ticlopidine - adverse effects
Ticlopidine - analogs & derivatives
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Our hypothesis was that the continuation of clopidogrel does not increase the risk of eye hemorrhage, compared to patients not treated with clopidogrel, when a peribulbar anesthesia is required. Our prospective case-control study enrolled two groups of 1,000 patients scheduled for intraocular eye surgery requiring a peribulbar block. Patients treated with clopidogrel were included in group A (1,000 patients). Patients who had never been treated with clopidogrel constituted the control group (group B, 1,000 patients). Hemorrhages were graded as follows: 1 = spot ecchymosis of eyelid and or subconjunctival hemorrhage; 2 = eyelid ecchymosis involving half the lid surface area; 3 = eyelid ecchymosis all around the eye, no increase in intraocular pressure; 4 = retrobulbar hemorrhage with increased intraocular pressure. Grade 1 hemorrhages were observed in 30 patients (3.0 %) in group A and in 20 patients (2.0 %) in group B. No grade 2, 3, or 4 hemorrhage was encountered. There was no significant difference in the grading of hemorrhage between the groups ( p  = 0.017). Clopidogrel was not associated with a significant increase in potentially sight-threatening local anesthetic complications.
ISSN:0913-8668
1438-8359
DOI:10.1007/s00540-012-1406-6