Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis. Despite the crucial role in immunity...

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Bibliographic Details
Published in:	Nature (London) 2015-10, Vol.526 (7575), p.660-665
Main Authors:	Shi, Jianjin, Zhao, Yue, Wang, Kun, Shi, Xuyan, Wang, Yue, Huang, Huanwei, Zhuang, Yinghua, Cai, Tao, Wang, Fengchao, Shao, Feng
Format:	Article
Language:	English
Subjects:	13 13/89 13/95 49/47 631/250/1933 631/250/262 631/250/516 64 64/60 82 82/83 Animals Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - antagonists & inhibitors Apoptosis Regulatory Proteins - chemistry Apoptosis Regulatory Proteins - deficiency Apoptosis Regulatory Proteins - metabolism Bone marrow Caspase 1 - metabolism Caspases - metabolism Cell death Cell Line Cells CRISPR-Cas Systems Enzymes Gangrene HIV Human immunodeficiency virus Humanities and Social Sciences Humans Inflammasomes - metabolism Inflammation Inflammation - enzymology Interleukin-1beta - metabolism Interleukin-1beta - secretion Lipopolysaccharides - pharmacology Macrophages - metabolism Male Mice Mice, Inbred C57BL multidisciplinary Mutation Necrosis Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism Physiological aspects Protein Processing, Post-Translational Protein Structure, Tertiary Proteins - chemistry Proteins - genetics Proteins - metabolism Science Substrate Specificity
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