Canine lymphoma: clinical and hematological aspects and treatment with the Madison-Wisconsin protocol/Linfoma canino: clinica, hematologia e tratamento com o protocolo de Madison-Wisconsin

Lymphoma is a neoplasm of high incidence in dogs, and has several clinical signs, depending on the tumor anatomical area and the extent of the disease. This study aimed to evaluate the clinical and hematological findings in dogs with lymphoma at diagnosis, and the clinical evolution during Madison-W...

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Bibliographic Details
Published in:Ciência rural 2011-07, Vol.41 (7), p.1245
Main Authors: de Capua, Maria Luisa Buffo, Dela Coleta, Flavia Eiras, Canesin, Ana Paula Massae Nakage, Godoy, Aline Vieira, Calazans, Sabryna Gouveia, Miotto, Mariana Rodrigues, Daleck, Carlos Roberto, Santana, Aureo Evangelista
Format: Article
Language:Spanish
Subjects:
Anemia
Cancer
Chemotherapy
Diagnosis
Dogs
Non-Hodgkin's lymphomas
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Summary:Lymphoma is a neoplasm of high incidence in dogs, and has several clinical signs, depending on the tumor anatomical area and the extent of the disease. This study aimed to evaluate the clinical and hematological findings in dogs with lymphoma at diagnosis, and the clinical evolution during Madison-Wisconsin chemotherapy protocol. Of the 18 dogs that underwent the study, 50% of the dogs had the multicentric form and 33% the cutaneous forms of the disease. The most common clinical sign was superficial lymphadenomegaly, combined to systemic signs of hyporexia, apathy and weight loss. The main hematological changes were anemia, thrombocytopenia and leukocytosis, associated with paraneoplastic syndromes. Complete remission was achieved in 27% of the animals and the one-year survival rate was 22%. There was a positive correlation between the hematocrit and survival time in dogs that died, which indicates the importance of anemia in the prognosis. It is suggested that the advanced stage of the disease may have contributed to the low remission and survival rates observed in this study.
ISSN:0103-8478