X-Ray Phase Nanotomography Resolves the 3D Human Bone Ultrastructure

Bone strength and failure are increasingly thought to be due to ultrastructural properties, such as the morphology of the lacuno-canalicular network, the collagen fiber orientation and the mineralization on the nanoscale. However, these properties have not been studied in 3D so far. Here we report t...

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Bibliographic Details
Published in:	PloS one 2012-08, Vol.7 (8), p.e35691
Main Authors:	Langer, Max, Pacureanu, Alexandra, Suhonen, Heikki, Grimal, Quentin, Cloetens, Peter, Peyrin, Françoise
Format:	Article
Language:	English
Subjects:	Absorption Aged Aged, 80 and over Algorithms Biocompatibility Bioengineering Biology Biomedical materials Bone and Bones - metabolism Bone and Bones - pathology Bone and Bones - ultrastructure Bone density Bone strength Cement Collagen Collagen - chemistry Engineering Female Fiber orientation Fibers Field of view Humans Image Processing, Computer-Assisted - methods Imaging Life Sciences Materials Science Measurement Medical imaging Medicine Mineralization Models, Statistical Nanotechnology - methods Normal Distribution Osteocytes - cytology Physics Physiological aspects Plywood Spatial discrimination Spatial resolution Three dimensional displays Three dimensional imaging Tissues Tomography Tomography, X-Ray Computed - methods Ultrastructure X-Rays
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