Comparison of the effects of mitochondria-targeted antioxidant 10- and a fragment of its molecule dodecyltriphenylphosphonium on carrageenan-induced acute inflammation in mouse model of subcuteneous air pouch

The effect of mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute infla...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-04, Vol.162 (6), p.730
Main Authors: Chelombitko, M.A, Averina, O.A, Vasileva, T.V, Dvorianinova, E.E, Egorov, M.V, Pletjushkina, O.Yu, Popova, E.N, Fedorov, A.V, Romashchenko, V.P, Ilyinskaya, O.P
Format: Article
Language:English
Subjects:
Antioxidants (Nutrients)
Bromine compounds
Carrageenan
Cytokines
Inflammation
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Summary:The effect of mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute inflammation in the subcutaneous air pouch. In our model, SkQ1 demonstrated a strong anti-inflammatory effect that manifested in a decrease in the absolute number of inflammatory cells, mainly neutrophils, and their relative number in parallel with an increase in macrophages and mast cell content in the inflammatory exudate. The concentration of proinflammatory cytokine IL-6 in the exudate also tended to decrease. C12TPP produced no significant effect on the inflammation process. Key Words: mitochondria-targeted antioxidants; SkQ1; C12TPP; acute inflammation; carrageenan
ISSN:0007-4888
DOI:10.1007/s10517-017-3699-9