Bioinformatic characterization of the Anoctamin Superfamily of Ca.sup.2+-activated ion channels and lipid scramblases

Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins. Results using these tools suggest that the Anoctamin Superfamily of cation and anion channels, as well as lipid scramblases, i...

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Bibliographic Details
Published in:PloS one 2018-03, Vol.13 (3), p.e0192851
Main Authors: Medrano-Soto, Arturo, Moreno-Hagelsieb, Gabriel, McLaughlin, Daniel, Ye, Zachary S, Hendargo, Kevin J, Saier, Milton H
Format: Article
Language:English
Subjects:
Analysis
Computational biology
Ion channels
Physiological aspects
Structure
Transport proteins
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Summary:Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins. Results using these tools suggest that the Anoctamin Superfamily of cation and anion channels, as well as lipid scramblases, includes three functionally characterized families: the Anoctamin (ANO), Transmembrane Channel (TMC) and Ca.sup.2+ -permeable Stress-gated Cation Channel (CSC) families; as well as four families of functionally uncharacterized proteins, which we refer to as the Anoctamin-like (ANO-L), Transmembrane Channel-like (TMC-L), and CSC-like (CSC-L1 and CSC-L2) families. We have constructed protein clusters and trees showing the relative relationships among the seven families. Topological analyses suggest that the members of these families have essentially the same topologies. Comparative examination of these homologous families provides insight into possible mechanisms of action, indicates the currently recognized organismal distributions of these proteins, and suggests drug design potential for the disease-related channel proteins.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0192851