Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats

Radiotherapy for malignant pelvic disease is often followed by acute radiation colitis (ARC). It has been reported that sucralfate treatment has a protective effect against ARC, though the mechanisms of action are unknown. The effects of sucralfate on X-ray radiation-induced apoptosis was studied at...

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Bibliographic Details
Published in:JOURNAL OF RADIATION RESEARCH 2006, Vol.47 (1), p.1-8
Main Authors: Matsuu-Matsuyama, Mutsumi, Shichijo, Kazuko, Okaichi, Kumio, Ishii, Kouji, Wen, Chung Yang, Fukuda, Eiichiro, Nakayama, Toshiyuki, Nakashima, Masahiro, Okumura, Yutaka, Sekine, Ichiro
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - drug effects
Cells, Cultured
Colitis
Complications and side effects
Dosage and administration
Epithelial Cells - drug effects
Epithelial Cells - pathology
Epithelial Cells - radiation effects
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Intestinal Mucosa - radiation effects
Male
Prevention
Radiation Injuries - etiology
Radiation Injuries - pathology
Radiation Injuries - prevention & control
Radiation-Protective Agents - administration & dosage
Radiotherapy
Rats
Rats, Wistar
Risk factors
Sucralfate
Sucralfate - administration & dosage
Treatment Outcome
Whole-Body Irradiation
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Summary:Radiotherapy for malignant pelvic disease is often followed by acute radiation colitis (ARC). It has been reported that sucralfate treatment has a protective effect against ARC, though the mechanisms of action are unknown. The effects of sucralfate on X-ray radiation-induced apoptosis was studied at 4 Gy in the colonic crypt cells of rats. Sucralfate enemas given prior to radiation resulted in the following： (1) reduction in number of apoptotic colonic crypt cells; (2) reduction in number of caspase-3 positive cells; (3) decreases in p53 accumulation and p21 expression; (4) decreases of Bax/Bcl-2 ratio. The protective effects of sucralfate against ARC may be partially due to the suppression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region.
ISSN:0449-3060
1349-9157
DOI:10.1269/jrr.47.1