Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway

p53, circRNAs and miRNAs are important components of the regulatory network that activates the EMT program in cancer metastasis. In prostate cancer (PCa), however, it has not been investigated whether and how p53 regulates EMT by circRNAs and miRNAs. Here we show that a Amotl1-derived circRNA, terme...

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Bibliographic Details
Published in:	Oncogene 2019-04, Vol.38 (14), p.2516-2532
Main Authors:	Yang, Zhan, Qu, Chang-Bao, Zhang, Yong, Zhang, Wen-Feng, Wang, Dan-Dan, Gao, Chun-Cheng, Ma, Long, Chen, Jin-Suo, Liu, Kai-Long, Zheng, Bin, Zhang, Xin-Hua, Zhang, Man-Li, Wang, Xiao-Lu, Wen, Jin-Kun, Li, Wei
Format:	Article
Language:	English
Subjects:	13/89 14/32 38/1 38/77 38/90 42/44 45/44 45/61 631/337/384 631/67/322 631/80/84/2027 64/60 82/51 82/58 Aged Angiomotins Apoptosis Biosynthesis Cadherins - genetics Cancer metastasis Care and treatment Cell adhesion & migration Cell Biology Cell Line, Tumor Cell migration Cell Movement - genetics Cell Proliferation - genetics Cellular signal transduction Chromosome 5 Development and progression Disease Progression Down-Regulation - genetics E-cadherin Gene Expression Regulation, Neoplastic - genetics Genes Genetic aspects Human Genetics Humans Internal Medicine Male Medicine Medicine & Public Health Membrane Proteins - genetics Metastases MicroRNA MicroRNAs - genetics Middle Aged Nuclear Proteins Oncology p53 Protein PC-3 Cells Prostate cancer Prostatectomy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology RNA-Binding Proteins - genetics Signal Transduction - genetics Tumor proteins Tumor Suppressor Protein p53 - genetics Up-Regulation - genetics Vimentin Vimentin - genetics
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