Progress in trial registration in Latin America and the Caribbean, 2007-2013/Registro de ensayos clinicos en America Latina y el Caribe/Registro de ensaios clinicos na America Latina e no Caribe.(Special report texto en ingles)

• Published in: Revista panamericana de salud pública 2017-12, Vol.41 (8)
• Main Authors: Rodriguez-Feria, Pablo, Cuervo, Luis Gabriel
• Format: Article
• Language: English
• ISSN: 1020-4989

This descriptive study identifies trends in clinical trial registration in the World Health Organization International Clinical Trial Registry Platform (ICTRP) for Latin America and the Caribbean (LAC), from 2007-2013, and provides adjusted estimates for registration rates by population and publications (2007-2011). Trends and data are presented by subregion and language in interactive graphs, including annual registration rates by population (2007-2011) and publications (LILACS and MEDLINE) listed in SCIENTI Network (Science and Technology Indicators). Of the 11 945 clinical trials involving LAC countries, 8 282 were in South America, with Brazil leading at 4 070 (49%); 2 421 in North and Central America, with Mexico leading at 1 886 (78%); and 1 242 in the Caribbean, with Puerto Rico leading at 857 (69%). After adjusting by population and publication rates Chile, Panama, Argentina, and Peru led registration rates per 1 million inhabitants. Variations in the number of trials per year are quite substantial. Clinical trial registration increased in a steady yet inconsistent way. The implementation of the Policy on Research for Health has been followed by an increase in countries that require registration and have established clinical trial registries. However, there is room for improvement in adherence throughout LAC. Trial registration is offered gratis by Brazilian, Cuban, Peruvian, and United States registries, among others. Keywords Clinical trials as topic; health policy; research; ethics; policy; Pan American Health Organization; Caribbean region; Central America; South America; North America. En este estudio descriptivo se establecen las tendencias en cuanto al registro de ensayos clinicos en la Plataforma de Registros Internacionales de Ensayos Clinicos (ICTRP) de la Organizacion Mundial de la Salud (OMS) en America Latina y el Caribe en el periodo 2007-2013, y se incluyen calculos ajustados de las tasas de registro por poblacion y por publicaciones (2007-2011). Las tendencias y los datos se presentan por subregiones e idiomas en graficos interactivos, y ademas se incluyen las tasas anuales de registro por poblacion (2007-2011) y publicaciones (LILACS y MEDLINE) que figuran en la Red ScienTi (indicadores de ciencia y tecnologia). De los 11 945 ensayos clinicos realizados en paises de America Latina y el Caribe, 8 282 tuvieron lugar en America del Sur, en donde Brasil lleva la delantera con 4 070 (49 %); 2 421 se realizaron en America del Norte y Cen