Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

‘Reactive oxygen species’ (ROS) is an umbrella term for an array of derivatives of molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the different ROS leads to molecular damage, denoted as ‘oxidative distress’. Here we focus on ROS at physiological levels and t...

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Bibliographic Details
Published in:	Nature reviews. Molecular cell biology 2020-07, Vol.21 (7), p.363-383
Main Authors:	Sies, Helmut, Jones, Dean P.
Format:	Article
Language:	English
Subjects:	631/80/304 631/80/86 Adaptation Aging Animals Antioxidants Antioxidants - metabolism Biochemistry Biomedical and Life Sciences Cancer Research Cell Biology Cellular stress response Changing environments Clinical trials Cytokines Developmental Biology DNA binding proteins Electron transport Electron transport chain Environmental changes Environmental factors Forecasts and trends Growth factors Humans Hydrogen peroxide Hydrogen sulfide Immune system Immunosuppressive agents Irradiation Life Sciences Lipids Metabolism Mitochondria Molecular interactions Muscles NAD(P)H oxidase Neoplasms - physiopathology Nitric oxide Nutrition Oxidants Oxidases Oxidation-Reduction Oxidative Stress Oxidizing agents Oxygen Peroxides Physiological aspects Physiology Post-translation Protein Processing, Post-Translational Radiation Radiation damage Reactive oxygen species Reactive Oxygen Species - metabolism Review Article Selenium Signal Transduction Signaling Skeletal muscle Stem Cells Superoxide Superoxide anions Trace elements Transcription factors
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