Superparamagnetic iron oxide nanoparticles conjugated with A[beta] oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. A[beta] oligomers (A[beta]Os), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2020-11, Vol.18 (1)
Main Authors: Liu, Xiao-ge, Zhang, Lun, Lu, Shuai, Liu, Dong-qun, Huang, Ya-ru, Zhu, Jie, Zhou, Wei-wei, Yu, Xiao-lin, Liu, Rui-tian
Format: Article
Language:English
Subjects:
Alzheimer's disease
Care and treatment
Health aspects
Iron oxides
Magnetic properties
Monoclonal antibodies
Nanoparticles
Oligomers
Online Access:Get full text
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Summary:Alzheimer's disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. A[beta] oligomers (A[beta]Os), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against A[beta]Os and promote A[beta] clearance may have great value for AD treatment. We here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with A[beta] oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-A[beta] properties of W20 and XD4 by inhibiting A[beta] aggregation, attenuating A[beta]O-induced cytotoxicity and increasing microglial phagocytosis of A[beta]. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice. These results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-020-00723-1