metabolism and retinal degeneration

The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide ([NAD.sup.+]), particularly in regards to its intermediates, such as nicotinamide and nicotinic acid known as niacin, and also nicotinamide riboside. Besides its participation as a coenzyme in the red...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2021-07, Vol.22 (1)
Main Authors: Pirvu, Andreea Silvia, Andrei, Ana Marina, Stanciulescu, Elena Camelia, Banita, Ileana Monica, Pisoschi, Catalina Gabriela, Jurja, Sanda, Ciuluvica, Radu
Format: Article
Language:English
Subjects:
Care and treatment
Cell metabolism
Development and progression
DNA repair
Genetic aspects
Health aspects
Retinal degeneration
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Summary:The recent years has revealed an intense interest in the study of nicotinamide adenine dinucleotide ([NAD.sup.+]), particularly in regards to its intermediates, such as nicotinamide and nicotinic acid known as niacin, and also nicotinamide riboside. Besides its participation as a coenzyme in the redox transformations of nutrients during catabolism, [NAD.sup.+] is also involved in DNA repair and epigenetic modification of gene expression and also plays an essential role in calcium homeostasis. Clinical and experimental data emphasize the age-dependent decline in [NAD.sup.+] levels and its relation with the onset and progression of various age-related diseases. Maintaining optimal levels of [NAD.sup.+] has aroused a therapeutic interest in such pathological conditions; [NAD.sup.+] being currently regarded as an important target to extend health and lifespan. Based on a systematic exploration of the experimental data and literature surrounding the topic, this paper reviews some of the recent research studies related to the roles of the pyridine nucleotide family focusing on biosynthesis, [NAD.sup.+] deficiency-associated diseases, pathobiochemistry related to retinal degeneration and potential therapeutic effects on human vision as well. Key words: pyridine nucleotide family, [NAD.sup.+], niacin, nicotinamide riboside, retinal degeneration, [NAD.sup.+] therapeutic target
ISSN:1792-0981
DOI:10.3892/etm.2021.10102