Effects of OPRM1 and DRD2 on brain structure in drug-naïve adolescents: Genetic and neural vulnerabilities to substance use

Genetic variants in the opioid receptor mu 1 (OPRM1) and dopamine receptor d2 (DRD2) genes are implicated in behavioral phenotypes related to substance use disorders (SUD). Despite associations among OPRM1 (rs179971) and DRD2 (rs6277) genes and structural alterations in neural reward pathways implic...

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Bibliographic Details
Published in:Psychopharmacology 2022-01, Vol.239 (1), p.141-152
Main Authors: Picci, Giorgia, Fishbein, Diana H., VanMeter, John W., Rose, Emma J.
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Biomedical and Life Sciences
Biomedicine
Brain - diagnostic imaging
Brain research
Child
Cortex (cingulate)
Data collection
Dopamine D2 receptors
Dopamine receptors
Drug use
Drugs and youth
Female
Genetic aspects
Genetic diversity
Health aspects
Humans
Longitudinal Studies
Magnetic resonance imaging
Male
Neuroanatomy
Neurosciences
Nucleus accumbens
Opioid receptors (type mu)
Opioids
Original Investigation
Pharmaceutical Preparations
Pharmacology/Toxicology
Phenotypes
Psychiatry
Putamen
Receptors
Receptors, Dopamine D2 - genetics
Receptors, Opioid, mu - genetics
Reinforcement
Risk factors
Substance-Related Disorders - genetics
Teenagers
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