NMDA-Receptor Antagonists Reduce Skin Sensitivity to the TRPV1-Receptor Agonist Capsaicin

Glutamate receptors are widely represented in the central and peripheral nervous systems, which determines their involvement in central and peripheral nociception. In particular, NMDA receptors are localized at the dermal-epidermal junction. TRPV1 receptors in skin-innervating unmyelinated nerve fib...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical chemistry journal 2021-12, Vol.55 (9), p.857-859
Main Authors: Ivanova, E. A., Matyushkin, A. I., Voronina, T. A.
Format: Article
Language:English
Subjects:
Capsaicin
Glutamate
Medicine
Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Phenols
Protein kinases
Skin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glutamate receptors are widely represented in the central and peripheral nervous systems, which determines their involvement in central and peripheral nociception. In particular, NMDA receptors are localized at the dermal-epidermal junction. TRPV1 receptors in skin-innervating unmyelinated nerve fibers can functionally interact with NMDA receptors in the calcium/calmodulin-dependent protein kinase II and protein kinase C cascades. Herein, the effect of noncompetitive NMDA-receptor antagonists on peripheral skin sensitization caused by subcutaneous injection of the TRPV1-receptor agonist capsaicin was evaluated using different routes of administration. The high-affinity antagonist of NMDA receptors MK-801 and the low-affinity antagonist of NMDA receptors hemantane administered to mice by cutaneous application and systemic (intraperitoneal for hemantane and subcutaneous for MK-801) and subcutaneous injection in the metatarsal region reduced the duration of the response to subcutaneous injection of capsaicin solution in the metatarsal region.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-021-02509-7