Ajuba Overexpression Promotes Breast Cancer Chemoresistance and Glucose Uptake through TAZ-GLUT3/Survivin Pathway

The LIM protein Ajuba has been implicated in the development of human cancers. To date, its expression pattern and biological significance in breast cancers (BC) have not been fully investigated. In the current study, we examined Ajuba protein levels in 93 invasive ductal carcinoma specimens by immu...

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Bibliographic Details
Published in:	BioMed research international 2022, Vol.2022 (1), p.3321409
Main Authors:	Li, Xiang, Zhao, Gexin, Mi, Xiaoyi, Xu, Tonghong, Li, Xinmin, Liu, Bin
Format:	Article
Language:	English
Subjects:	Ajuba protein Analysis Apoptosis Biomedical research Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cancer Cancer therapies Care and treatment Cell cycle Cell Line, Tumor Cell Proliferation Chemoresistance Drug Resistance, Neoplasm - genetics Epithelial cells Epithelium Esophageal cancer Experiments Female Gene expression Gene Expression Regulation, Neoplastic Gene sequencing Gene set enrichment analysis Glucose Glucose metabolism Glucose Transporter Type 3 - genetics Health aspects Humans Immunohistochemistry Invasiveness Laboratory animals LIM Domain Proteins - genetics LIM protein Medical prognosis Medical research Metastases Metastasis Paclitaxel Pancreatic cancer Prevention Proteins Ribonucleic acid Risk factors RNA Signal transduction Signaling Statistical analysis Survival Survivin Survivin - genetics TEA Domain Transcription Factors - genetics Tumors
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