Dixon chemical shift MR sequences for demonstrating of bone marrow vertebral metastasis

• Published in: Egyptian journal of radiology and nuclear medicine 2022-08, Vol.53 (1), p.1-11
• Main Authors: Zarad, Carmen Ali, Elmaaty, Ali Ahmed Abou, Shanab, Waleed S. Abo
• Format: Article
• Language: English
• Subjects: Bone marrow; Chemical shift; CT imaging; Dixon; Medical imaging equipment; Medical research; Medicine, Experimental; Metastasis; Opposed phase; PET imaging; Vertebral metastasis
• ISSN: 0378-603X; 2090-4762
• DOI: 10.1186/s43055-022-00861-6

Background This study aimed to investigate the diagnostic performance and clinical utility of different MR Dixon sequences in the characterization of vertebral metastasis in a patient with a history of malignant neoplasm and compare the results with 18-F FDG PET CT. Patients were subjected to MR imaging of the dorsal and lumbosacral spine (1.5 T MR machine) using conventional MR, T2 Dixon and T1 post-contrast Dixon. Results This study involved 40 patients (45% female and 55% male) with 161 metastatic lesions and median age 61.5 years. The sensitivities of T1 post-contrast water-only (WO), fat-only (FO) and opposed-phase (OP) Dixon for diagnosis of vertebral metastasis were 92.6%, 89.4% and 83.1%, respectively, while the sensitivity of T2 (WO, OP) Dixon was 78.3% with 100% specificity for both T1 and T2 Dixon. There were excellent positive clinical utilities of T1 post-contrast WO (0.925), FO (0.894) and OP (0.826) Dixon with the good positive clinical utility of T2 Dixon (0.783) for lesion finding. There were fair negative clinical utilities of T1 WO (0.636) and FO (0.553) Dixon with poor negative clinical utilities of T1 OP (0.429), T2 WO and OP (0.375) Dixon for lesion screening. 15% was the best in-phase/opposed-phase ratio for differentiation between metastatic and benign vertebral lesions. Conclusions MR Dixon techniques are sensitive and specific for the diagnosis of vertebral metastasis. T1 post-contrast and T2 Dixons have excellent and good positive clinical utilities for lesion finding with fair and poor negative clinical utilities for lesion screening, respectively.