Various Gynaecological Disorders and Haematological Abnormalities in HIV Seropositive Women

Gynaecological problems including menstrual disorders, vaginal infections, PID, STD, cervical dysplasias are common among HIV-positive women. Haematological abnormalities are a common complication of HIV infection involving all lineages of blood cells. HIV infects [CD.sub.4] T-lymphocytes, monocytes...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2014-12, Vol.29 (S1), p.S79
Main Authors: Kharb, Ramanjit Kaur Simmi, Nanda, Smiti, Ghalaut, P.S, Lallar, Meenakshi
Format: Article
Language:English
Subjects:
Dysplasia
Health aspects
HIV (Viruses)
HIV infection
HIV testing
Medical research
Medicine, Experimental
Women
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Summary:Gynaecological problems including menstrual disorders, vaginal infections, PID, STD, cervical dysplasias are common among HIV-positive women. Haematological abnormalities are a common complication of HIV infection involving all lineages of blood cells. HIV infects [CD.sub.4] T-lymphocytes, monocytes, and macrophages. Though a considerable number of studies are available in western literature on HIV and related gynaecological problems and prevalence of anemia in HIV women, very few studies are available from this part of the world. HIV-positive women attending the outpatient clinics at PGIMS Rohtak were evaluated to study these problems and to note the relation of above conditions with CD4 count and ART. A total of 200 HIV seropositive females in the age group 18 to 50 years attending the ART clinic were studied. Serological reactivity to HIV-1 and 2 was determined by enzyme immunoassay tests. After an informed consent all women were interviewed regarding their menstrual, medical and treatment history. Pelvic examination, cervicovaginal pap smears, papanicolauu staining was done. Blood samples were taken to determine the CD4 lymphocytes count using standard flow cytometric technique. Haematological Profile was studied in all the patients. The HIV seropositive women had a higher incidence of menstrual disorders (23.5%), vaginal infections (candidiasis-43.2%, bacterial vaginosis-47.7%, trichomoniasis-3%), cervical dysplasias which were worse with increasing immunosuppression (at lower CD4 levels: 19.4% and 7.3% respectively). 70% patients had anaemia especially in cases with increasing immunosuppression. Serum folate and serum ferritin levels were significantly lower, more so at lower CD4 levels. Serum iron levels were higher at lower CD4 levels. The screening of HIV seropositive women should be carried in a large number of patients.
ISSN:0970-1915