Are Uric Acid Values Surrogate for Insulin Resistance in Apparently Healthy Subjects Across a Spectrum of Body Mass Index?

The concept of insulin resistance initially proposed in diabetic patients is now known to be associated with major public health problems, including obesity, hypertension, coronary artery disease and metabolic syndrome. Serum uric acid values are also elevated in the above conditions and proposed to...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2014-12, Vol.29 (S1), p.S106
Main Authors: Puneeth, A, Manjrekar, Poornima A, Hegde, Anupama, Rukmini, M.S, Gopal, R. Madan
Format: Article
Language:English
Subjects:
Body mass index
Coronary heart disease
Diabetics
Hypertension
Insulin resistance
Uric acid
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Summary:The concept of insulin resistance initially proposed in diabetic patients is now known to be associated with major public health problems, including obesity, hypertension, coronary artery disease and metabolic syndrome. Serum uric acid values are also elevated in the above conditions and proposed to reflect the insulin-resistant state. Aim was to determine whether serum uric acid levels can be used as a surrogate for Insulin resistance calculated as HOMA-IR in apparently healthy, normal weight, overweight and obese population. Cross sectional study done in 150 subjects of both genders aged 20- 40 years divided equally based on their BMI into 3 group namely normal weight, overweight and obese as per NIH classification. Fasting plasma glucose, fasting serum insulin and serum uric acid were estimated. HOMA-IR was calculated. Mean waist circumference, waist-hip ratio, fasting insulin, fasting glucose, uric acid and HOMA-IR were found to be elevated in both overweight and obese groups. Mean uric acid levels were 4.9, 5.4 and 6.3 and mean HOMA-IR values are 2.2, 3.3 and 7.3 respectively in normal weight, overweight and obese subjects. Significant correlation of uric acid with insulin resistance calculated as HOMAIR was not found in any of the three groups. There was incremental increase in fasting glucose, fasting insulin, uric acid and HOMAIR from normal weight to overweight to obese subjects in a systematic proportion. Significant correlation of uric acid with fasting insulin and insulin resistance was not seen and hence cannot be used as the surrogate marker for insulin resistance in apparently healthy population.
ISSN:0970-1915