To Evaluate Serum Amylase Levels In Metabolic Syndrome

INTRODUCTION: Few recent studies have reported low serum amylase levels to be a risk factor of metabolic syndrome (MetS) associated with worse lipid profile parameters, suggesting an endocrine-exocrine relationship in pancreas. However they also reported increasing prevalence of stroke and requireme...

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Published in:Indian journal of clinical biochemistry 2022-05, Vol.32 (S1), p.S122
Main Authors: Dokwal, Sumit, Gahlaut, Veena Singh, Kulshrestha, Manish Raj, Bansal, Piyush
Format: Article
Language:English
Subjects:
Amylases
Blood proteins
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Summary:INTRODUCTION: Few recent studies have reported low serum amylase levels to be a risk factor of metabolic syndrome (MetS) associated with worse lipid profile parameters, suggesting an endocrine-exocrine relationship in pancreas. However they also reported increasing prevalence of stroke and requirement for drug treatment for hypercholesterolemia with higher amylase levels. Other studies have reported elevated amylase levels in diabetes. AIMS AND OBJECTIVE : To evaluate serum amylase levels in metabolic syndrome. MATERIALAND METHOD: Study group comprised of 200 subjects (25-75 yrs) with MetS. Persons with any other chronic and acute illness, renal dysfunction and drug intake (OCP, steroids, aspirin etc.) known to influence amylase levels, persons with high urea levels and those with amylase 200 IU/L were also excluded. Control group comprised of 50 healthy controls. RESULTS AND CONCLUSION: Amylase levels was significantly higher than in control group (71.80 [+ or -] 29.06 vs 59.9 [+ or -] 21.40 IU/L, p=0.010). Amylase levels positively correlated with serum triglycerides (r=0.210, p=0.032), ALT (r=0.223, p=0.023) and urea (r=0.209, p=0.039) and were negatively correlated with HDL levels (r=0.267, p=0.006) in the study group. The study found higher amylase levels in MetS which were correlated significantly with higher TG and lower HDL levels. Hyperinsulinemia a feature of MetS is known to increase amylase secretion. Pancreatic tissue in Type 2 DM has been reported to have inflammatory hypercellularity, loss of cell adhesion and paracrine communication, apoptosis, ECM remodeling, fibrosis in both islet (endocrine) and acinar(exocrine) tissues. This may be leading to increase release of amylase as a nonfunctional plasma protein, reflecting the slow continuous pancreatic inflammation and damage. KEY WORDS: serum amylase, inflammation, fibrosis, HDL, acinar
ISSN:0970-1915