A Study of Insulin Resistance, B -Cell Function and Lipid Profile in Type II Diabetes Mellitus

Type 2 diabetes is not a disease but rather a heterogenous group of multifactorial syndromes characterized by elevated fasting blood glucose caused by relative or absolute deficiency of insulin. It is associated with a cluster of interrelated plasma glucose, lipid and lipoprotein abnormalities, incl...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.34 (S1), p.S121
Main Authors: Rathore, Mohini, Rawtani, Jairam, Kanwar, Gulab
Format: Article
Language:English
Subjects:
Analysis
Blood sugar
Cholesterol
Diabetics
Exercise
Insulin resistance
Low density lipoproteins
Mediation
Type 2 diabetes
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Summary:Type 2 diabetes is not a disease but rather a heterogenous group of multifactorial syndromes characterized by elevated fasting blood glucose caused by relative or absolute deficiency of insulin. It is associated with a cluster of interrelated plasma glucose, lipid and lipoprotein abnormalities, including a predominance of total cholesterol, elevated triglycerides and reduced HDL. This study was conducted to evaluate the effect of altered lipid profiles of the established cases of diabetes mellitus patients on their insulin resistance states as depicted by their HOMA-IR and HOMA-P scores. This study is a cross-sectional analysis of the samples collected at New Medical College, Kota. One hundred and four subjects [greater than or equal to] 40 years were selected from the elderly population, which were established cases of type 2 DM. The same number of healthy non-diabetic subjects were evaluated. When the diabetic group and the control group were compared, significant statistical difference was observed in fasting serum glucose, cholesterol, triglycerides, VLDL, LDL HbA1c, serum insulin, HOMA-IR and HOMA-[beta] scores. Above findings reflect that there is a positive correlation between diabetes and altered lipid profile, serum insulin, Hb1Ac and HOMA-IR. There is a high prevalence of dyslipidemia, which might be playing a major role in the development of cardiovascular diseases and cerebrovascular accidents among diabetic patients. Efforts to achieve lifestyle changes, such as weight reduction, physical exercise and smoking cessation should be encouraged and initiated first and then followed by mediation with lipid-lowering drugs prescribed in evidence-based necessary conditions.
ISSN:0970-1915